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At present, the advanced pancreatic cancer is known to be one of the most resistant malignancies on chemotherapy. To improve the efficacy of chemotherapy, we shifted the aim of chemotherapy from a tumor regression to long-term survival, and sought for a repeatable regimen with little toxicity. Some of the novel (repeatable) regimens used a combination of 5-FU/S-1, CDDP and paclitaxel performed for 10 patients with advanced pancreatic cancer (4 cases of Stage IVa and 6 cases of Stage IVb). As a result, the survival ratios of one and two years were 85.7% and 22.9%, respectively. The efficacy rate was 50% (5 cases of PR and 5 cases of NC). Hematological adverse reactions over grade 3 were observed in 8 out of 10 cases, although the decrease of platelet count was observed only in 2 cases (grade 3 and 4). The majority of hematological adverse reactions over grade 3 were leukocytepenia and anemia which were easy to control safely. All of non-hematological adverse reactions were observed under grade 2 and did not disrupt the maintenance of chemotherapy.
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
January 2016,
Journal of thoracic disease,
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
June 2012,
Cancer,
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
November 2008,
World journal of gastroenterology,
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
September 2006,
Gan to kagaku ryoho. Cancer & chemotherapy,
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
June 1976,
The Japanese journal of surgery,
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
December 2014,
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi,
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
January 2006,
Nihon rinsho. Japanese journal of clinical medicine,
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
September 1996,
Oncology (Williston Park, N.Y.),
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
April 2006,
Best practice & research. Clinical gastroenterology,
Susumu Yamamitsu, and
Hiromichi Kimura, and
Yoshiyuki Yamada, and
Noriaki Inui, and
Shigema Hiyama, and
Kouichi Hirata, and
Yasutoshi Kimura, and
Tetsuhiko Shirasada
January 2003,
International journal of radiation oncology, biology, physics,
