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A metabolic study with tissue from a virilizing arrhenoblastoma, using as precursors [7-3H]pregnenolone, [7-3H]17alpha-hydroxypregnenolone,[4-14C]17alpha-hydroxyprogesterone and [4-14C]testosterone, revealed that in spite of a deficient activity of 3beta-hydroxysteroid dehydrogenase-5-isomerase the overall production of testosterone was compensated by an increased activity of a lyase converting [4-14C]17alpha-hydroxyprogesterone to testosterone (via androstenedione) and was comparable to the production obtained by normal ovarian tissue. The masculinizing effects of the tumour in vivo were most probably caused by accumulation of testosterone due to deficiencies in enzymes catabolizing testosterone to 17-ketosteroids and its aromatization to oestrogen. The unique property of the arrhenoblastoma to convert [4-14C]17alpha-hydroxyprogesterone to [4-14C]11-deoxycortisol (Reichstein's compound S) suggests an adrenal origin of the tumour which may explain its limited capacity to aromatize testosterone.
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
January 1960,
Acta obstetricia et gynecologica Scandinavica,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
September 1972,
Proceedings of the Royal Society of Medicine,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
November 1990,
Clinical endocrinology,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
April 1999,
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
July 1960,
Danish medical bulletin,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
January 1951,
Bulletin de la Federation des societes de gynecologie et dobstetrique de langue francaise,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
February 1947,
The Journal of clinical endocrinology and metabolism,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
June 1953,
Nederlands tijdschrift voor geneeskunde,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
June 1953,
Nederlands tijdschrift voor geneeskunde,
I Maschler, and
J Weidenfeld, and
B Fleischer, and
E N Ehrenfeld, and
M Finkelstein
December 1991,
Clinical obstetrics and gynecology,
