BIOMAT Database Logo BIOMAT Database Logo

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors. 2006

Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
Institut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria. Gerhard.Puerstinger@uibk.ac.at

A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC(50)<100nM) and selectivity (SI>1000) against the pestivirus BVDV (bovine viral diarrhea virus).

UI MeSH Term Description Entries
D007093 Imidazoles Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D011725 Pyridines Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D001908 Diarrhea Viruses, Bovine Viral A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes. Bovine Viral Diarrhea Viruses,Diarrhea Virus, Bovine Viral,Bovine Diarrhea Virus,Bovine Pestivirus,Bovine Diarrhea Viruses,Bovine Pestiviruses,Diarrhea Virus, Bovine,Diarrhea Viruses, Bovine,Pestiviruses, Bovine,Virus, Bovine Diarrhea,Viruses, Bovine Diarrhea
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular

Related Publications

Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
New antiinflammatory agents. 2. 5-Phenyl-3H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones: a new class of nonsteroidal antiinflammatory agents with potent activity like glucocorticoids.
July 1992, Journal of medicinal chemistry,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
New bronchodilators. 1. 1,5-Substituted 1H-imidazo[4,5-c]quinolin-4(5H)-ones.
October 1992, Journal of medicinal chemistry,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
Synthesis of potential anticancer agents: imidazo[4,5-c]pyridines and imidazo[4,5-b]pyridines.
October 1987, Journal of medicinal chemistry,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
Synthesis and analgesic activity of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines.
September 1978, Journal of medicinal chemistry,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
1-Amino-substituted 4-methyl-5H-pyrido[3',4':4,5]pyrrolo[3,2-c]pyridines: a new class of antineoplastic agents.
September 1987, Journal of medicinal chemistry,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
Directed solid-phase synthesis of trisubstituted imidazo[4,5-c]pyridines and imidazo[4,5-b]pyridines.
October 2014, ACS combinatorial science,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as nonacidic antiinflammatory agents.
November 1978, Journal of medicinal chemistry,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
Synthesis of some new 2-(substituted-phenyl)imidazo[4,5-c] and [4,5-b]pyridine derivatives and their antimicrobial activities.
August 2023, Molecular diversity,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
4-Benzyl-6-bromo-2-phenyl-4H-imidazo[4,5-b]pyridine.
March 2010, Acta crystallographica. Section E, Structure reports online,
Gerhard Puerstinger, and Jan Paeshuyse, and Piet Herdewijn, and Jef Rozenski, and Erik De Clercq, and Johan Neyts
Biological Activity of Amidino-Substituted Imidazo [4,5-b]pyridines.
December 2022, Molecules (Basel, Switzerland),
Copied contents to your clipboard!