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Electrically stimulated skeletal muscle can be used in many ways to pump blood. The important physiological characteristics of skeletal muscle for use in a cardiac assist role are presented. The force developed by a twitch and tetanic contraction are quantitated and the considerations in the choice of the stimulus applied to the innervating motor nerve are discussed. The importance of stimulus frequency and duration of the stimulus train are presented in terms of the stroke volume produced by skeletal muscle contracting around a pouch. The effect that preload has on pouch stroke volume and muscle blood flow are demonstrated. Finally an example is given in which cardiac output is augmented by an untrained, electrically stimulated, canine rectus abdominis muscle wrapped around a pouch connected between the apex of the left ventricle and the aorta. In this study, the augmentation in cardiac output was measured when the skeletal muscle was contracted after each second, third, and fourth ventricular contraction. The augmentation was 46% +/- 4, 31% +/- 7, and 25% +/- 4, respectively, for the three contraction regimens. Although electrically stimulated skeletal muscle can be used as a power source to assist the failing heart, the optimum application is yet to be discovered. Important considerations in selecting the optimal application are preload, stimulus train duration, train rate, and muscle blood flow.
L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
August 1997,
Pacing and clinical electrophysiology : PACE,
L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
April 2001,
IEEE transactions on bio-medical engineering,
L A Geddes, and
S F Badylak, and
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W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
April 1995,
Bailliere's clinical neurology,
L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
June 1997,
IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society,
L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
April 1985,
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L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
July 1994,
Israel journal of medical sciences,
L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
November 2008,
Journal of applied physiology (Bethesda, Md. : 1985),
L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
September 1968,
Life sciences,
L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
November 1995,
The American journal of physiology,
L A Geddes, and
S F Badylak, and
J l Wessale, and
W Janas, and
J D Bourland, and
W A Tacker, and
L Stevens
February 1990,
The British journal of surgery,
