-transparent.png){kind=logo}
To investigate the possible mechanisms involved in the alterations in sensitivity to pain in diabetic rats, we examined the influence of diabetes induced by streptozotocin (STZ) on the functions of the neuronal systems that contain substance P (SP) within the spinal cord. The threshold for pain perception as determined by a tail-pinch test was significantly reduced in diabetic rats. The levels of SP in the spinal cord from diabetic rats (116.9 +/- 16.3 pmol/g tissue) were significantly lower than those from the control rats (190.2 +/- 14.1 pmol/g tissue). Diabetic rats were found to have a significant increase in the number of binding sites for SP in dorsal spinal cord. The concentrations of binding sites in diabetic rats and in control rats were 102.1 +/- 17.3 fmol/mg protein and 52.6 +/- 6.6 fmol/mg protein, respectively. These data indicate that STZ-induced diabetic rats exhibit supersensitivity to SP in the spinal cord. This may be correlated, in part, with the reduction in the threshold for perception of pain in diabetic animals.
J Kamei, and
M Ogawa, and
Y Kasuya
May 1993,
General pharmacology,
J Kamei, and
M Ogawa, and
Y Kasuya
May 2015,
Cytokine,
J Kamei, and
M Ogawa, and
Y Kasuya
January 1992,
Journal fur Hirnforschung,
J Kamei, and
M Ogawa, and
Y Kasuya
September 2009,
European journal of pain (London, England),
J Kamei, and
M Ogawa, and
Y Kasuya
July 1978,
The Journal of physiology,
J Kamei, and
M Ogawa, and
Y Kasuya
January 1988,
The Japanese journal of physiology,
J Kamei, and
M Ogawa, and
Y Kasuya
February 2004,
Brain research,
J Kamei, and
M Ogawa, and
Y Kasuya
April 2001,
Investigative ophthalmology & visual science,
J Kamei, and
M Ogawa, and
Y Kasuya
January 1990,
Peptides,
J Kamei, and
M Ogawa, and
Y Kasuya
August 1991,
Neuroscience letters,
