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Treatment of HL-60 cells with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) for 48 h induced expression of mRNA of beta A chain of activin A/erythroid differentiation factor. Under the same condition, interferon-gamma caused a slight increase in beta A chain mRNA, whereas 1 alpha, 25-dihydroxyvitamin D3, dimethylsulfoxide and all-trans-retinoic acid failed to induce this mRNA in HL-60 cells. Furthermore, 4 h-treatment with TPA or lipopolysaccharide (LPS) induced a marked increase in beta A chain mRNA levels in interferon-gamma-pretreated HL-60 cells. In the cells pretreated with 1 alpha, 25-dihydroxyvitamin D3, TPA and LPS induced as little increase in beta A chain mRNA as in the control cells. Neither alpha nor beta B chain mRNA was detected in any sample. These results indicate that interferon-gamma has a priming effect on the activation of activin A/erythroid differentiation factor gene by TPA or LPS in HL-60 cells.
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June 1992,
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research,
S Takahashi, and
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E Ogata
August 1992,
Nihon rinsho. Japanese journal of clinical medicine,
S Takahashi, and
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January 1998,
Biochemical and biophysical research communications,
S Takahashi, and
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April 1994,
Blood,
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August 1993,
Blood,
S Takahashi, and
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H Shibai, and
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E Ogata
October 2002,
Nucleic acids research,
S Takahashi, and
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H Shibai, and
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E Ogata
January 1987,
Leukemia research,
S Takahashi, and
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March 1984,
The Journal of biological chemistry,
S Takahashi, and
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April 2003,
Experimental & molecular medicine,
S Takahashi, and
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May 1991,
Cancer research,
