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The effects of starvation, feeding and pentagastrin on gastric mucosal adenylate cyclase (AC) and phosphodiesterase (PDE) activity were studied in the rat. 1. Starvation for 24 hrs and 48 hrs reduced both NaF stimulated and basal AC activities. 2. Feeding of starved rats slowly raised the AC activity up to 430% within 4 hrs after feeding. This effect was more pronounced under basal conditions than with NaF stimulation. 3. A single i.p. injection of pentagastrin (125 mug/kg) caused a stimulation of basal AC lasting 45 min, which was followed by a subsequent decrease in the basal and NaF stimulated enzyme activity. 4. PDE activity was not influenced by starvation and feeding but underwent a transient inhibition by pentagastrin. Accordingly gastric mucosal cAMP levels after starvation, feeding and pentagastrin are regulated by changes in AC and not in PDE activity. The rise in AC activity after feeding appears to be related to functions other than H+ and pepsin secretion.
H J Ruoff, and
K F Sewing
November 1977,
Biochemical pharmacology,
H J Ruoff, and
K F Sewing
June 1979,
Experientia,
H J Ruoff, and
K F Sewing
August 1977,
The American journal of digestive diseases,
H J Ruoff, and
K F Sewing
August 1977,
Gastroenterology,
H J Ruoff, and
K F Sewing
April 1979,
Acta hepato-gastroenterologica,
H J Ruoff, and
K F Sewing
February 1977,
The American journal of physiology,
H J Ruoff, and
K F Sewing
August 1978,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
H J Ruoff, and
K F Sewing
August 1981,
Cell calcium,
H J Ruoff, and
K F Sewing
February 1973,
Biochemical pharmacology,
H J Ruoff, and
K F Sewing
January 1976,
Recent advances in studies on cardiac structure and metabolism,
