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Murine colon 26 adenocarcinoma causes a progressive weight loss and physiological changes associated with cachexia when it grows to a certain size. By the use of this tumor model several types of cytostatics were examined for their ability to alleviate cachexia. Among them, 5'-deoxy-5-fluorouridine could reverse a progressive weight loss and improve hypoglycemia, hyperglucocorticism, and hepatic malfunctions, as well as inhibiting the tumor growth. Cyclophosphamide, nimustine, and 2'-deoxy-5-fluorouridine were only slightly effective in reversing the wasting, while 5-fluorouracil, tegafur, mitomycin C, cis-platinum, and doxorubicin were not active. Within 3 days after 5'-deoxy-5-fluorouridine was administered to cachectic mice with large tumor burdens, the wasting was immediately reversed even at doses in which there was increase or no significant reduction in tumor growth. These results indicate that the anticachectic activity of 5'-deoxy-5-fluorouridine is independent of its antiproliferative activity.
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
June 1989,
Japanese journal of cancer research : Gann,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
March 1997,
Japanese journal of cancer research : Gann,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
April 1989,
Pharmaceutical research,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
September 1994,
Gan to kagaku ryoho. Cancer & chemotherapy,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
January 1994,
Anticancer research,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
January 1992,
Cancer research,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
January 1983,
Cancer chemotherapy and pharmacology,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
July 1985,
Japanese journal of cancer research : Gann,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
August 1985,
Neurologia medico-chirurgica,
Y Tanaka, and
H Eda, and
K Fujimoto, and
T Tanaka, and
T Ishikawa, and
H Ishitsuka
April 1980,
European journal of cancer,
