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Lack of involvement of the G-CSF gene by chromosomal translocation t(15;17) in acute promyelocytic leukemia. 1990
S Tanaka, and
H Nishigaki, and
S Misawa, and
M Taniwaki, and
H Nakagawa, and
H Yashige, and
S Horiike, and
K Kashima, and
J Inazawa, and
Y Sonoda
Third Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Using a human G-CSF cDNA as a probe, we analyzed the t(15;17) breakpoint by Southern blot analysis with conventional and/or pulsed-field gel electrophoresis in 12 patients with acute promyelocytic leukemia. The results did not show the rearrangement, deletion, or restriction fragment length polymorphism within the gene and in the surrounding sequences.
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