BIOMAT Database Logo BIOMAT Database Logo

Falls in blood pressure in patients with obstructive sleep apnoea after long-term nasal continuous positive airway pressure treatment. 2006

Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Department of Physical Therapeutics, Kyoto University Hospital, Kyoto, Japan. chink@kuhp.kyoto-u.ac.jp

OBJECTIVE Effective treatment of obstructive sleep apnoea (OSA) with nasal continuous positive airway pressure (nCPAP) lowers blood pressure (BP). The long-term effects of nCPAP treatment on BP in OSA patients are not well known. The time period of such treatment sufficient to lower BP in OSA patients is also not known. We investigated compliance with long-term nCPAP therapy and its effects on BP. METHODS This observational study involved 66 OSA patients [59 men, seven women; mean age, 51 (48-54) years; body mass index (BMI), 28.7 (27.7-29.7) kg/m; apnoea and hypopnoea, 50.3 (45.6-55.0)/h; 95% confidence intervals]. BP and BMI were measured before the study and at two checkpoints after usage of nCPAP [620 (552-688) and 1071 (1000-1143) days]. RESULTS The different times between the first and second checkpoints for detecting objective compliance were 17 (4-30) min (P = 0.003). Diastolic BP decreased by 5.9 (3.1-8.7) mmHg after 600 days nCPAP treatment and by 4.6 (2.0-7.2) mmHg after 1000 days (P = 0.0006). Systolic BP and BMI did not change significantly. Usage of nCPAP treatment for a daily average of 3 h was needed to achieve a significant decrease in diastolic BP [7.4 (4.3-10.6) mmHg, P < 0.0001]. Diastolic BP of normotensive OSA patients did not change significantly by nCPAP treatment, but that of hypertensive OSA patients decreased significantly within 1 month-3 years of nCPAP treatment whether or not medication was used. CONCLUSIONS In patients with severe OSA, the use of nCPAP for a daily average of 3 h would be sufficient to decrease the diastolic BP of hypertensive OSA patients.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010349 Patient Compliance Voluntary cooperation of the patient in following a prescribed regimen. Client Adherence,Client Compliance,Non-Adherent Patient,Patient Adherence,Patient Cooperation,Patient Noncompliance,Patient Non-Adherence,Patient Non-Compliance,Patient Nonadherence,Therapeutic Compliance,Treatment Compliance,Adherence, Client,Adherence, Patient,Client Compliances,Compliance, Client,Compliance, Patient,Compliance, Therapeutic,Compliance, Treatment,Cooperation, Patient,Non Adherent Patient,Non-Adherence, Patient,Non-Adherent Patients,Non-Compliance, Patient,Nonadherence, Patient,Noncompliance, Patient,Patient Non Adherence,Patient Non Compliance,Patient, Non-Adherent,Therapeutic Compliances,Treatment Compliances
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D015992 Body Mass Index An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI Quetelet Index,Quetelet's Index,Index, Body Mass,Index, Quetelet,Quetelets Index
D045422 Continuous Positive Airway Pressure A technique of respiratory therapy, in either spontaneously breathing or mechanically ventilated patients, in which airway pressure is maintained above atmospheric pressure throughout the respiratory cycle by pressurization of the ventilatory circuit. (On-Line Medical Dictionary [Internet]. Newcastle upon Tyne(UK): The University Dept. of Medical Oncology: The CancerWEB Project; c1997-2003 [cited 2003 Apr 17]. Available from: http://cancerweb.ncl.ac.uk/omd/) Airway Pressure Release Ventilation,BiPAP Bilevel Positive Airway Pressure,BiPAP Biphasic Positive Airway Pressure,Bilevel Positive Airway Pressure,Biphasic Positive Airway Pressure,APRV Ventilation Mode,Bilevel Continuous Positive Airway Pressure,Biphasic Continuous Positive Airway Pressure,CPAP Ventilation,Nasal Continuous Positive Airway Pressure,nCPAP Ventilation,APRV Ventilation Modes,Ventilation Mode, APRV,Ventilation Modes, APRV,Ventilation, CPAP,Ventilation, nCPAP

Related Publications

Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Severe obstructive sleep apnoea treated with long term nasal continuous positive airway pressure.
January 1985, Thorax,
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Humidified nasal continuous positive airway pressure in obstructive sleep apnoea.
August 2003, The European respiratory journal,
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Treatment of obstructive sleep apnoea with nasal continuous positive airway pressure in stroke.
October 2001, The European respiratory journal,
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Long-term continuous positive airway pressure compliance in females with obstructive sleep apnoea.
November 2013, The European respiratory journal,
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Reduced cardiac sympathetic autonomic tone after long-term nasal continuous positive airway pressure in obstructive sleep apnoea syndrome.
March 1999, Clinical physiology (Oxford, England),
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Long-term nasal continuous positive airway pressure treatment lowers blood pressure in patients with obstructive sleep apnea regardless of age.
October 2010, Hypertension research : official journal of the Japanese Society of Hypertension,
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea.
November 2003, Journal of internal medicine,
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Sleep-related breathing disorders. 5. Nasal continuous positive airway pressure treatment for obstructive sleep apnoea.
October 1995, Thorax,
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Long-term treatment with continuous positive airway pressure improves quality of life in obstructive sleep apnoea syndrome.
July 2000, The European respiratory journal,
Kazuo Chin, and Takaya Nakamura, and Ken-ichi Takahashi, and Kensuke Sumi, and Hisako Matsumoto, and Akio Niimi, and Shunichi Fukuhara, and Michiaki Mishima, and Takashi Nakamura
Effect of short term graded withdrawal of nasal continuous positive airway pressure on systemic blood pressure in patients with obstructive sleep apnoea.
July 1996, Blood pressure,
Copied contents to your clipboard!