BIOMAT Database Logo BIOMAT Database Logo

TRAIL, caspases and maturation of normal and leukemic myeloid precursors. 2006

Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100, Ferrara, Italy.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) is a membrane-bound cytokine molecule that belongs to the family of tumor necrosis factor (TNF). Members of this family share diverse biological effects, including induction of apoptosis and/or promotion of cell survival. Identification of TRAIL has generated considerable enthusiasm for its ability to induce apoptotic cell death in a variety of tumor cells, by engaging the death receptors TRAIL-R1/DR4 and TRAIL-R2/DR5, while sparing most normal cells. Beside its anticancer activity, several studies have suggested a role for endogenously expressed TRAIL in hemopoiesis. In this review, we summarize the knowledge about the different lineage-specific roles of TRAIL and its receptors in hemopoiesis regulation. Moreover, the complex interplay among the signaling pathways triggered by TRAIL/TRAIL-receptors in myeloid cells is discussed in some detail.

UI MeSH Term Description Entries
D006410 Hematopoiesis The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY). Hematopoiesis, Medullary,Haematopoiesis,Medullary Hematopoiesis
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014411 Neoplastic Stem Cells Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS. Cancer Stem Cells,Colony-Forming Units, Neoplastic,Stem Cells, Neoplastic,Tumor Stem Cells,Neoplastic Colony-Forming Units,Tumor Initiating Cells,Cancer Stem Cell,Cell, Cancer Stem,Cell, Neoplastic Stem,Cell, Tumor Initiating,Cell, Tumor Stem,Cells, Cancer Stem,Cells, Neoplastic Stem,Cells, Tumor Initiating,Cells, Tumor Stem,Colony Forming Units, Neoplastic,Colony-Forming Unit, Neoplastic,Initiating Cell, Tumor,Initiating Cells, Tumor,Neoplastic Colony Forming Units,Neoplastic Colony-Forming Unit,Neoplastic Stem Cell,Stem Cell, Cancer,Stem Cell, Neoplastic,Stem Cell, Tumor,Stem Cells, Cancer,Stem Cells, Tumor,Tumor Initiating Cell,Tumor Stem Cell,Unit, Neoplastic Colony-Forming,Units, Neoplastic Colony-Forming
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis
D053221 TNF-Related Apoptosis-Inducing Ligand A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form. Tumor Necrosis Factor Ligand Superfamily Member 10,Apo-2 Ligand,Apo-2L Protein,CD253 Antigen,TNF Superfamily, Member 10,TRAIL Protein,Antigen, CD253,Apo 2 Ligand,Apo 2L Protein,Apoptosis-Inducing Ligand, TNF-Related,TNF Related Apoptosis Inducing Ligand
D020169 Caspases A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur. Caspase
D023461 Myeloid Progenitor Cells Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS. Stem Cells, Myeloid,CFU-GEMM,Colony-Forming Units, Granulocyte-Erythroid-Macrophage-Megakaryocyte,Common Myeloid Progenitors,GEMM-CFU,Granulocyte-Erythroid-Macrophage-Megakaryocyte Colony-Forming Unit,Cell, Myeloid Progenitor,Cell, Myeloid Stem,Cells, Myeloid Progenitor,Cells, Myeloid Stem,Colony Forming Units, Granulocyte Erythroid Macrophage Megakaryocyte,Colony-Forming Unit, Granulocyte-Erythroid-Macrophage-Megakaryocyte,Common Myeloid Progenitor,Granulocyte Erythroid Macrophage Megakaryocyte Colony Forming Unit,Granulocyte-Erythroid-Macrophage-Megakaryocyte Colony-Forming Units,Myeloid Progenitor Cell,Myeloid Progenitor, Common,Myeloid Progenitors, Common,Myeloid Stem Cell,Myeloid Stem Cells,Progenitor Cell, Myeloid,Progenitor Cells, Myeloid,Progenitor, Common Myeloid,Progenitors, Common Myeloid,Stem Cell, Myeloid,Unit, Granulocyte-Erythroid-Macrophage-Megakaryocyte Colony-Forming,Units, Granulocyte-Erythroid-Macrophage-Megakaryocyte Colony-Forming

Related Publications

Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway.
October 2002, Blood,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells.
August 2003, Journal of leukocyte biology,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Leukemic cell maturation: variability of the myeloid leukemic cell phenotype.
January 1986, Blood cells,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Protein kinase C isoforms in normal and leukemic neutrophils: altered levels in leukemic neutrophils and changes during myeloid maturation in chronic myeloid leukemia.
January 2002, Leukemia research,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Developmental regulation of normal and leukemic human B cell precursors.
January 1990, Progress in clinical and biological research,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
[Thymidine kinase in normal and leukemic myeloid cells].
May 1967, Klinische Wochenschrift,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Fibrinolytic activity in normal and leukemic myeloid differentiation.
February 1982, Haematologica,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells.
June 2007, Journal of leukocyte biology,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Immunobiologic differences between normal and leukemic human B-cell precursors.
November 1988, Proceedings of the National Academy of Sciences of the United States of America,
Federica Corallini, and Daniela Milani, and Vanessa Nicolin, and Paola Secchiero
Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells.
March 1991, Blood,
Copied contents to your clipboard!