BIOMAT Database Logo BIOMAT Database Logo

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. 1990

D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Department of Microbiology-Immunology, Northwestern University, Chicago, IL 60611.

A secreted inhibitor of angiogenesis that is controlled by a tumor suppressor gene in hamster cells has been found to be similar to a fragment of the platelet and matrix protein thrombospondin. The two proteins were biochemically similar and immunologically crossreactive and could substitute for one another in two functional assays. Human thrombospondin inhibited neovascularization in vivo and endothelial cell migration in vitro, as does the hamster protein, gp140. gp140 sensitized smooth muscle cells to stimulation by epidermal growth factor, as does human thrombospondin. The thrombospondin gene has been localized on human chromosome 15. These results demonstrate a function for the ubiquitous adhesive glycoprotein thrombospondin that is likely to be important in the normal physiological down-regulation of neovascularization. In addition, they raise the possibility that thrombospondin may be one of a number of target molecules through which a tumor suppressor gene could act to restrain tumor growth.

UI MeSH Term Description Entries
D008562 Membrane Glycoproteins Glycoproteins found on the membrane or surface of cells. Cell Surface Glycoproteins,Surface Glycoproteins,Cell Surface Glycoprotein,Membrane Glycoprotein,Surface Glycoprotein,Glycoprotein, Cell Surface,Glycoprotein, Membrane,Glycoprotein, Surface,Glycoproteins, Cell Surface,Glycoproteins, Membrane,Glycoproteins, Surface,Surface Glycoprotein, Cell,Surface Glycoproteins, Cell
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009389 Neovascularization, Pathologic A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions. Angiogenesis, Pathologic,Angiogenesis, Pathological,Neovascularization, Pathological,Pathologic Angiogenesis,Pathologic Neovascularization,Pathological Angiogenesis,Pathological Neovascularization
D001792 Blood Platelets Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002884 Chromosomes, Human, Pair 15 A specific pair of GROUP D CHROMOSOMES of the human chromosome classification. Chromosome 15
D006023 Glycoproteins Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins. C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein

Related Publications

D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis.
December 1999, Proceedings of the National Academy of Sciences of the United States of America,
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth.
January 2002, Journal of cellular and molecular medicine,
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Thrombospondin-1: an inhibitor of angiogenesis.
January 2001, Haemostasis,
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin.
January 1994, Cold Spring Harbor symposia on quantitative biology,
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Placental protein 14 and progestagen-dependent endometrial protein are immunologically indistinguishable.
January 1986, Human reproduction (Oxford, England),
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Thrombospondin-1-induced migration is functionally dependent upon focal adhesion kinase.
January 2008, Vascular and endovascular surgery,
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis.
April 2014, Oncogene,
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase.
November 1989, Biochemical and biophysical research communications,
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Silica-associated systemic sclerosis is clinically, serologically and immunologically indistinguishable from idiopathic systemic sclerosis.
December 1990, The British journal of dermatology,
D J Good, and P J Polverini, and F Rastinejad, and M M Le Beau, and R S Lemons, and W A Frazier, and N P Bouck
Regulation of tumor angiogenesis by thrombospondin-1.
April 2006, Biochimica et biophysica acta,
Copied contents to your clipboard!