-transparent.png){kind=logo}
When we analyzed the in vivo efficacy of cytokine administration in murine allogeneic bone marrow chimeras, mitogen-induced responses to ConA, PHA, LPS, or PWM were increased by the in vivo administration of human recombinant granulocyte colony-stimulating factor (rG-CSF), human recombinant interleukin 2 (rIL-2), or WEHI-3B conditioned medium (CM). Furthermore, we found increased alloreactive mixed lymphocyte reactions (MLRs) against donor and/or host type alloantigens in spleen cells from (BALB/c----C3H/He) chimeras, although cytotoxic activity against BALB/c or C3H/He target cells was not detected in spleen cells from these chimeras. Since no significant increase of T cells or Ia positive cells was observed, some functional activation, rather than changes in the cell count, appeared to relate to increase immunoreactivity. An increased IL-2 production in spleen cells from chimeras injected with cytokine was observed shortly after the cessation of cytokine administration. Thereafter, an IL-2 production in these chimeras decreased around 45 days after bone marrow transplantation and then recovered nearly to the control level. An increased IL-2 responsiveness was also observed in spleen cells from these chimeras. These findings suggest that the in vivo administration of rG-CSF as well as rIL-2 or WEHI-3B CM (IL-3) can modulate the immunoreactivity in chimeras via the network of immune systems.
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
November 1983,
Igaku kenkyu. Acta medica,
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
August 1987,
Bone marrow transplantation,
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
May 1981,
Clinical immunology and immunopathology,
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
August 1989,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
November 1991,
Journal of immunology (Baltimore, Md. : 1950),
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
February 1995,
Leukemia & lymphoma,
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
January 1996,
Immunology letters,
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
September 2008,
Zhonghua er ke za zhi = Chinese journal of pediatrics,
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
January 1999,
Transplantation proceedings,
M Imamura, and
H Fujimoto, and
S Hashino, and
T Fukuhara, and
M Kobayashi, and
M Kasai, and
K Sakurada, and
T Miyazaki
August 1994,
Immunobiology,
