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Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. 2006
Zhijian Zhao, and
Julie A O'Brien, and
Wei Lemaire, and
David L Williams, and
Marlene A Jacobson, and
Cyrille Sur, and
Doug J Pettibone, and
Philip R Tiller, and
Sheri Smith, and
George D Hartman, and
Scott E Wolkenberg, and
Craig W Lindsley
Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 4, West Point, PA 19486, USA. zhijian_zhao@merck.com <zhijian_zhao@merck.com>
This Letter describes the synthesis and SAR, developed through an iterative analog library approach, of potent and selective non-sarcosine-derived GlyT1 inhibitors.
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