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In this prospective study, the effect of the antiproteinase aprotinin on anticoagulation during cardiopulmonary bypass was compared with placebo treatment in a randomized double-blind fashion. The kallikrein-inhibiting capacity was significantly increased in aprotinin-treated patients and decreased in the control patients. The intrinsic clotting system was also inhibited by aprotinin. We demonstrated during cardiopulmonary bypass and in vitro a significantly prolonged activated clotting time and a remarkable prolongation of the activated partial thromboplastin time by aprotinin at low heparin concentrations, whereas the antithrombin III consumption was significantly reduced. Aprotinin synergistically enhanced the anticoagulation by heparin, which allowed reduced heparinization. This is of clinical importance for use in both heparin-resistant and heparin-sensitive patients undergoing cardiopulmonary bypass and may also have advantages for routine use during bypass to reduce the adverse effects of heparin-protamine complexes.
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W van Oeveren, and
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L Eijsman, and
C R Wildevuur
November 1991,
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A A de Smet, and
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L Eijsman, and
C R Wildevuur
July 1992,
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A A de Smet, and
M C Joen, and
W van Oeveren, and
K J Roozendaal, and
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C R Wildevuur
November 1998,
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A A de Smet, and
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K J Roozendaal, and
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C R Wildevuur
April 1994,
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A A de Smet, and
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M P Harder, and
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C R Wildevuur
March 1988,
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A A de Smet, and
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K J Roozendaal, and
M P Harder, and
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C R Wildevuur
January 1989,
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A A de Smet, and
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C R Wildevuur
November 1992,
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A A de Smet, and
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K J Roozendaal, and
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L Eijsman, and
C R Wildevuur
March 2009,
Perfusion,
A A de Smet, and
M C Joen, and
W van Oeveren, and
K J Roozendaal, and
M P Harder, and
L Eijsman, and
C R Wildevuur
December 1987,
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A A de Smet, and
M C Joen, and
W van Oeveren, and
K J Roozendaal, and
M P Harder, and
L Eijsman, and
C R Wildevuur
January 1993,
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