Biomaterial Database

Thalamic afferents from the brain stem. An experimental study using retrograde single and double labelling with HRP and iron-dextran in the rat. I. Medial and lateral reticular formation. 1990

P Petrovický

Anatomical Institute, Charles University Medical Faculty, Prague.

The reticulo-thalamic projection of the rat was studied in single and double experiments using 51 injections of HRP and/or iron-dextran. The medial reticular formation (excluding the ncl. pedunculo-pontinus, subncl. compactus, see Part II) sends out projections to the ncll. intralaminares (IL), ncl. mediodorsalis (MD), ncl. ventralis medialis (VM), ncl. ventralis lateralis (VL), ncl. ventralis basalis (VB) and ncl. posterior (PO) of the thalamus. The mesencephalic RF (ncl. cuneiformis and ncl. subcuneiformis) projects to all the above mentioned nuclei. The rhombencephalic RF (ncl. pontis oralis, ncl. pontis caudalis, ncl. gigantocellularis et paragigantocellularis dorsalis et lateralis) projects to the posterior IL (ncl. parafascicularis and ncl. centromedianus) and to the MD, pars paralaminaris. The pontine RF (ncl. pontis oralis et caudalis) projects to the posterior IL and to the medial part of the ncl. parafascicularis. The RF of the pons and the upper oblongata projects to the VL, VB and PO. The lateral RF (ncl. parvocellularis) projects solely from the tiers around the ncl. n. VII. to the posterior IL in what is a scanty projection. We found no connections projecting from the medial or lateral RF to the midline nuclei, to the lateral nuclei or to the ncl. commissurae posterioris; the projection to the ncl. reticularis thalami was left unstudied. The reticulo-thalamic pathways exhibit marked laterality. The mesencephalic RF projects to the thalamus in what is pronounced ipsilateral predominance, the pontine RF in ipsilateral predominance, the upper oblongata RF equally ipsi- and contralaterally, and the lower oblongata RF with a predominance of the contralateral component. Collateralization (double labelled cells) was found projecting solely to the IL and MD regions. It was both ipsilateral and contralateral. The discoveries included the topographical organization of the reticulo-thalamic projection: a major antero-posterior in the rhombencephalon and a mediolateral in the projections from the mesencephalon and from the pons. The most substantial projection was found aiming at the posterior IL nuclei (ncl. parafascicularis-centrum medianum), a less substantial one to the ventral and posterior nuclei, and the scantiest to the anterior IL nuclei (ncl. paracentralis, ncl. centralis lateralis).

UI	MeSH Term	Description	Entries
D007505	Iron-Dextran Complex	A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in a viscous solution containing 50 mg/ml of iron. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292)	Dextran-Iron Complex,Dexferrum,Dextrofer,Feosol,Ferridextran,Hematran,Icar,Imfergen,Imferon,Imperon,Imposil,InFed,Norferan,Dextran Iron Complex,Iron Dextran Complex
D009475	Neurons, Afferent	Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.	Afferent Neurons,Afferent Neuron,Neuron, Afferent
D012154	Reticular Formation	A region extending from the PONS & MEDULLA OBLONGATA through the MESENCEPHALON, characterized by a diversity of neurons of various sizes and shapes, arranged in different aggregations and enmeshed in a complicated fiber network.	Formation, Reticular,Formations, Reticular,Reticular Formations
D001933	Brain Stem	The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.	Brainstem,Truncus Cerebri,Brain Stems,Brainstems,Cerebri, Truncus,Cerebrus, Truncus,Truncus Cerebrus
D006735	Horseradish Peroxidase	An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology.	Alpha-Peroxidase,Ferrihorseradish Peroxidase,Horseradish Peroxidase II,Horseradish Peroxidase III,Alpha Peroxidase,II, Horseradish Peroxidase,III, Horseradish Peroxidase,Peroxidase II, Horseradish,Peroxidase III, Horseradish,Peroxidase, Ferrihorseradish,Peroxidase, Horseradish
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013194	Staining and Labeling	The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.	Histological Labeling,Staining,Histological Labelings,Labeling and Staining,Labeling, Histological,Labelings, Histological,Stainings
D013788	Thalamus	Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.	Thalamencephalon,Thalamencephalons
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus