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Sprague-Dawley rats were separated in 4 groups. G1 received streptozotocin (ST). G2 received nicotinamide (NC) followed by ST. G3 was a NC control and G4 was a citrate control. The rats were sacrificed after 28 h and the islets isolated. Histamine and histaminase were determined. In the islets there was an increase in histamine content in G1 and a smaller increase in G2. The first two groups differ significantly and also in relation to the control groups. A decrease in islet histaminase does not seem responsible for the increased histamine, since group 2 (NC + ST) which had no diabetes, had a lower activity than group 1 (ST). It is suggested that histamine liberation by ST may be related to the diabetogenic effect of this drug.
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
May 1998,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
October 1976,
The Journal of biological chemistry,
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
August 1998,
Diabetes research and clinical practice,
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
January 1981,
Zeitschrift fur experimentelle Chirurgie,
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
March 1976,
Clinical endocrinology,
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
October 1990,
Journal of ethnopharmacology,
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
January 1977,
Acta physiologica latino americana,
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
January 1971,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
March 1991,
Transplantation,
M S Azevedo, and
I J Silva, and
J F Raposo, and
I F Neto, and
J G Falcão, and
C F Manso
August 1981,
Endocrinology,
