Effects of swimming training on bone mass and the GH/IGF-1 axis in diabetic rats. 2006

R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
Department of Physical Education, State University of São Paulo (UNESP), Avenida 24A No. 1515, Caixa Postal 199, Bela Vista, Rio Claro, CEP 13506-900, SP, Brazil. ricardojosegomes@yahoo.com.br

The aim of this study was to examine the influence of moderate swimming training on the GH/IGF-1 growth axis and tibial mass in diabetic rats. Male Wistar rats were allocated to one of four groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Diabetes was induced with alloxan (35 mg/kg b.w.). The training program consisted of a 1h swimming session/day with a load corresponding to 5% of the b.w., five days/week for six weeks. At the end of the training period, the rats were sacrificed and blood was collected for quantification of the serum glucose, insulin, GH, and IGF-1 concentrations. Samples of skeletal muscle were used to quantify the IGF-1 peptide content. The tibias were collected to determine their total area, length and bone mineral content. The results were analyzed by ANOVA with P<0.05 indicating significance. Diabetes decreased the serum levels of GH and IGF-1, as well as the tibial length, total area and bone mineral content in the SD group (P<0.05). Physical training increased the serum IGF-1 level in the TC and TD groups when compared to the sedentary groups (SC and SD), and the tibial length, total area and bone mineral content were higher in the TD group than in the SD group (P<0.05). Exercise did not alter the level of IGF-1 in gastrocnemius muscle in nondiabetic rats, but the muscle IGF-1 content was higher in the TD group than in the SD group. These results indicate that swimming training stimulates bone mass and the GH/IGF-1 axis in diabetic rats.

UI MeSH Term Description Entries
D007334 Insulin-Like Growth Factor I A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor. IGF-I,Somatomedin C,IGF-1,IGF-I-SmC,Insulin Like Growth Factor I,Insulin-Like Somatomedin Peptide I,Insulin Like Somatomedin Peptide I
D008297 Male Males
D010805 Physical Conditioning, Animal Diet modification and physical exercise to improve the ability of animals to perform physical activities. Animal Physical Conditioning,Animal Physical Conditionings,Conditioning, Animal Physical,Conditionings, Animal Physical,Physical Conditionings, Animal
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013006 Growth Hormone A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized. Growth Hormone, Recombinant,Pituitary Growth Hormone,Recombinant Growth Hormone,Somatotropin,Somatotropin, Recombinant,Growth Hormone, Pituitary,Growth Hormones Pituitary, Recombinant,Pituitary Growth Hormones, Recombinant,Recombinant Growth Hormones,Recombinant Pituitary Growth Hormones,Recombinant Somatotropins,Somatotropins, Recombinant,Growth Hormones, Recombinant,Recombinant Somatotropin
D013550 Swimming An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
D013977 Tibia The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally. Tibias
D015519 Bone Density The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS. Bone Mineral Content,Bone Mineral Density,Bone Densities,Bone Mineral Contents,Bone Mineral Densities,Density, Bone,Density, Bone Mineral
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats

Related Publications

R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
January 2021, Molecular and cellular endocrinology,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
June 2017, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
April 1986, The American journal of physiology,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
August 2009, Current cardiology reviews,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
January 2021, Frontiers in molecular neuroscience,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
June 2013, Nature reviews. Endocrinology,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
December 2023, The Journal of clinical endocrinology and metabolism,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
March 2013, Endocrine, metabolic & immune disorders drug targets,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
June 2016, The Journal of clinical endocrinology and metabolism,
R J Gomes, and M A R de Mello, and F H Caetano, and C Y Sibuya, and C A Anaruma, and G P Rogatto, and J R Pauli, and E Luciano
November 1995, Alcohol and alcoholism (Oxford, Oxfordshire),
Copied contents to your clipboard!