Biomaterial Database

[Evaluation of the gingival status by quantification of the T6 (CD1a) and HLA-DR antigens]. 1990

E Sagredo, and A Pino, and P Ibañez

Departamento de Biología Celular y Ciencias Morfológicas, Facultad de Farmacia, Universidad Del Pais Vasco, Alava España.

The number/mm2 of sections of Langerhans cells (LC's) expressing antigens T6 and/or HLA-DR was determined in eight human gingival samples which consisting of normal gingivae, contraceptive induced hyperplastic, traumatic, inflammatory and diphenylhydantoin hyperplasic gingivae. All samples, except those from normal gingivae, showed inflammatory and/or hyperplasic histopathological patterns. In the immunostained samples, LC's appeared in variable numbers and were randomly distributed between the keratinocytes. All pathological samples, except the inflammatory gingiva showed HLA-DR+ keratinocytes. Wilcoxon and Mann-Whitney statistical tests suggested the existence of three subpopulations of LC's: T6+/DR+; T6-/DR+ and T6+/DR-. The subpopulation T6+/DR+ was predominant in conditions of normal immune response. The subpopulation T6-/DR+ suggested the presence of newly incorporated LC's from the lamina propia. T6+/DR- subpopulations could indicate the existence of a system to avoid overstimulation. It is concluded that quantitative evaluation of T6 and HLA-DR expression was representative of the gingival conditions and the disease activity.

UI	MeSH Term	Description	Entries
D007801	Langerhans Cells	Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.	Langerhans Cell,Dendritic Cells, Dermal,Dendritic Cells, Epidermal,Dendritic Cells, Skin,Dermal Dendritic Cells,Epidermal Dendritic Cells,Skin Dendritic Cells,Cell, Dermal Dendritic,Cell, Epidermal Dendritic,Cell, Langerhans,Cell, Skin Dendritic,Cells, Dermal Dendritic,Cells, Epidermal Dendritic,Cells, Langerhans,Cells, Skin Dendritic,Dendritic Cell, Dermal,Dendritic Cell, Epidermal,Dendritic Cell, Skin,Dermal Dendritic Cell,Epidermal Dendritic Cell,Skin Dendritic Cell
D008297	Male		Males
D010672	Phenytoin	An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.	Diphenylhydantoin,Fenitoin,Phenhydan,5,5-Diphenylhydantoin,5,5-diphenylimidazolidine-2,4-dione,Antisacer,Difenin,Dihydan,Dilantin,Epamin,Epanutin,Hydantol,Phenytoin Sodium,Sodium Diphenylhydantoinate,Diphenylhydantoinate, Sodium
D002452	Cell Count	The number of CELLS of a specific kind, usually measured per unit volume or area of sample.	Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D003270	Contraceptive Agents	Chemical substances that prevent or reduce the probability of CONCEPTION.	Contraceptive,Contraceptive Effect,Contraceptive Effects,Contraceptives,Agents, Contraceptive,Effect, Contraceptive,Effects, Contraceptive
D005260	Female		Females
D005881	Gingiva	Oral tissue surrounding and attached to TEETH.	Gums,Interdental Papilla,Papilla, Interdental,Gum
D005885	Gingival Hyperplasia	Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)	Gingival Hyperplasias,Hyperplasia, Gingival,Hyperplasias, Gingival
D005891	Gingivitis	Inflammation of gum tissue (GINGIVA) without loss of connective tissue.	Gingivitides
D006684	HLA-DR Antigens	A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.	HLA-DR,Antigens, HLA-DR,HLA DR Antigens

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