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In anaesthetised cats, antibody microprobes were used to measure the release of immunoreactive substance P (irSP) in the lumbar dorsal horn during noxious cutaneous stimulation or high-intensity electrical stimulation of a hind limb nerve. The major region of irSP release detected was centered on the substantia gelatinosa, with lesser release at the dorsal cord surface. Release at these sites was unchanged by systemic administration of morphine, or of morphine followed by naloxone. During superfusion of the dorsal cord surface with high concentrations of morphine, irSP release in the substantia gelatinosa region was slightly reduced and surface release was not observed, effects not reversed by systemic naloxone administration. The results suggest that the analgesic action of morphine does not involve reduced release of SP in the spinal cord.
C R Morton, and
W D Hutchison, and
A W Duggan, and
I A Hendry
July 1980,
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C R Morton, and
W D Hutchison, and
A W Duggan, and
I A Hendry
June 1997,
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C R Morton, and
W D Hutchison, and
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I A Hendry
October 1987,
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C R Morton, and
W D Hutchison, and
A W Duggan, and
I A Hendry
May 1980,
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C R Morton, and
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I A Hendry
August 1979,
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C R Morton, and
W D Hutchison, and
A W Duggan, and
I A Hendry
November 1995,
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C R Morton, and
W D Hutchison, and
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I A Hendry
February 1996,
Sheng li xue bao : [Acta physiologica Sinica],
C R Morton, and
W D Hutchison, and
A W Duggan, and
I A Hendry
January 2016,
European journal of pharmacology,
C R Morton, and
W D Hutchison, and
A W Duggan, and
I A Hendry
January 1980,
Brain research,
C R Morton, and
W D Hutchison, and
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I A Hendry
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