-transparent.png){kind=logo}
Infection of Moloney mouse sarcoma virus (M-MSV) in adult mice of several inbred strains revealed that all strains except AKR are highly susceptible to M-MSV tumor development. F1 hybrids between AKR and CBA, DBA/2 or NIH mice are as resistant (93%) as the parental AKR strain, which indicates that resistance is transmitted as a dominant character. First backcross mice to the susceptible parent show a 3:1 ratio of resistant to susceptible mice. This is the expected ratio for two segregating loci which independently confer resistance. The incidence of resistant F2 mice is somewhat lower than expected. Further support for the two-gene hypothesis was obtained in second backcross mice. None of the major genes affecting MuLV infection (Fv-2 and H-2) seems to play any role in this system and no linkage was found with Thy. 1 and albino, dilute, agouti and brown markers.
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
October 1971,
Biulleten' eksperimental'noi biologii i meditsiny,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
June 1979,
International journal of cancer,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
March 1968,
Cancer research,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
January 1987,
Anticancer research,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
January 1980,
Journal of the National Cancer Institute,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
November 1970,
Cancer research,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
March 1970,
Infection and immunity,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
January 1982,
Bulletin du cancer,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
November 1982,
Cellular immunology,
A Colombatti, and
D Collavo, and
G Biasi, and
L Chieco-Bianchi
February 1981,
Cancer research,
