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[A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy]. 2006
Kotaro Shibahara, and
Takahiro Hirazuka, and
Manabu Yamamoto, and
Mizuki Ninomiya, and
Kojiro Mashino, and
Kyuzo Fuji, and
Tetsuo Ikeda, and
Tadashi Kahno
Dept. of Surgery, Oita Prefectural Hospital.
We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.
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