BIOMAT Database Logo BIOMAT Database Logo

Double-blind study of dilevalol and captopril, both in combination with hydrochlorothiazide, in patients with moderate to severe hypertension. 1990

B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Department of Medicine, Monash Medical Centre, Prince Henry's Hospital, Melbourne, Australia.

Sixty-one patients (41 men, 20 women) aged 29-73 years, with moderate to severe hypertension, were enrolled in a multicentre study to compare the efficacy, safety, and tolerability of dilevalol (D) and captopril (C). At the end of the baseline period, supine diastolic blood pressure (SuDBP) was 105-140 mm Hg on hydrochlorothiazide (HCTZ) 25 mg once daily and placebo t.i.d. Patients were randomly assigned to D + HCTZ (n = 29) or C + HCTZ (n = 32) and entered phase II titration of D (100-800 mg b.i.d.) or C (12.5 mg b.i.d. to 50 mg t.i.d.). If SuDBP was greater than 99 mm Hg, hydralazine was added (25 mg once daily to 50 mg b.i.d.). If SuDBP was less than or equal to 99 mm Hg, patients entered phase III, a 3-month maintenance period. Demographic profiles were not significantly different between the two groups. Baseline supine BP (mean +/- SEM) was similar in the two groups (D + HCTZ: 182 +/- 3/112 +/- 1; C + HCTZ: 179 +/- 4/113 +/- 1 mm Hg), as was baseline standing BP (D + HCTZ: 175 +/- 3/114 +/- 2; C +/- HCTZ: 173 +/- 4/113 +/- 1 mm Hg). At the end of phase II, there were no significant differences between treatments with respect to the changes in BP from baseline.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007741 Labetalol A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS. AH-5158,Albetol,Apo-Labetalol,Dilevalol,Labetalol Hydrochloride,Labetalol, (R,R)-Isomer,Labetolol,Normodyne,Presolol,R,R-Labetalol,SCH-19927,Trandate,AH 5158,AH5158,Apo Labetalol,ApoLabetalol,Hydrochloride, Labetalol,R,R Labetalol,SCH 19927,SCH19927
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D002216 Captopril A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline,Capoten,Lopirin,SQ-14,225,SQ-14,534,SQ-14225,SQ-14534,SQ 14,225,SQ 14,534,SQ 14225,SQ 14534,SQ14,225,SQ14,534,SQ14225,SQ14534
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females

Related Publications

B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Captopril/hydrochlorothiazide combination in elderly patients with mild-moderate hypertension. A double-blind, randomized, placebo-controlled study.
January 1986, Postgraduate medical journal,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Quinapril, hydrochlorothiazide, and combination in patients with moderate to severe hypertension.
July 1994, European heart journal,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
A multicenter, randomized double-blind study of valsartan/hydrochlorothiazide combination versus amlodipine in patients with mild to moderate hypertension.
September 2001, Journal of hypertension,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Controlled multicenter study with quinapril, hydrochlorothiazide, and combination in patients with moderate to severe hypertension.
July 1995, Journal of cardiovascular pharmacology,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Treating mild-to-moderate hypertension: a comparison of lisinopril-hydrochlorothiazide fixed combination with captopril and hydrochlorothiazide free combination.
December 1991, Journal of human hypertension,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Double-blind comparison of amlodipine and hydrochlorothiazide in patients with mild to moderate hypertension.
January 1988, Journal of cardiovascular pharmacology,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Double-blind comparison of amlodipine and hydrochlorothiazide in patients with mild to moderate hypertension.
May 1994, Clinical cardiology,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
[Efficacy and tolerability of captopril-hydrochlorothiazide vs amiloride-hydrochlorothiazide combination in mild to moderate arterial hypertension].
April 1989, La Clinica terapeutica,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Initial combination therapy with olmesartan/hydrochlorothiazide in moderate-to-severe hypertension.
April 2006, Journal of human hypertension,
B P McGrath, and P G Matthews, and W Louis, and L Howes, and J A Whitworth, and P S Kincaid-Smith, and I Fraser, and C Scheinkestel, and G MacDonald, and M Rallings
Comparative double-blind study of ramipril and captopril in mild to moderate essential hypertension.
April 1987, The American journal of cardiology,
Copied contents to your clipboard!