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Carbon-14-diphenylhydantoin (DPH) concentrated maximally in pancreatic islet cells of the toadfish 10 min after its intravenous administration. The islet cell-to-acinar-tissue ratio at this time was 6:1. The islet cell-to-liver ratio was 20:1. Iodine-125-paroiodo-DPH at 10 min in the toadfish showed an islet cell-to-acinar-tissue ratio of 1.7:1 and an islet cell-to-liver ratio of 2.3:1. When 14C-DPH was given to four patients 10-17 min before removal of norma pancreatic tissue and of an insulinoma in three of the patients, the concentration of radioactivity in the insulinoma was never greater than in the pancreas and concentrations in insulinoma and pancreas were always less than in liver in the same individual. Forty-five to 90 min after administration of 131I-DPH, the liver and pancreas were delineated in three patients but the insulinoma was not imaged. Five days after administration of 131I-DPH, the concentration of 131I radioactivity in excised tissue was greater in the insulinomas than in the pancreas of two patient but not sufficient to produce positive images of the insulinoma in the pancreas.
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
August 1974,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
August 1992,
Lymphokine and cytokine research,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
July 1974,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
January 1980,
Arzneimittel-Forschung,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
August 1984,
Antimicrobial agents and chemotherapy,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
January 1980,
Arzneimittel-Forschung,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
July 1956,
The International journal of applied radiation and isotopes,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
October 1976,
The Journal of endocrinology,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
January 1975,
Proceedings of the Western Pharmacology Society,
S Balachandran, and
W H Beierwaltes, and
R D Ice, and
S S Fajans, and
U Y Ryo, and
M J Redmond, and
K R Hetzel, and
S T Mosley, and
B Feldstein
January 1974,
Drug metabolism and disposition: the biological fate of chemicals,
