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Scleroderma renal crisis in a patient with anticentromere antibody-positive limited cutaneous systemic sclerosis. 2006
Toshiro Sugimoto, and
Mariko Soumura, and
Kiichiro Danno, and
Kenzo Kaji, and
Miki Kondo, and
Kunio Hirata, and
Jun Nakazawa, and
Takashi Uzu, and
Yoshihiko Nishio, and
Atsunori Kashiwagi
Department of Medicine, Shiga University of Medical Science, Seta, Otsu, 520-2192, Japan. toshiro@belle.shiga-med.ac.jp
We have encountered a 68-year-old Japanese woman with limited cutaneous systemic sclerosis who developed de novo onset of accelerated hypertension and renal dysfunction; thus we diagnosed scleroderma renal crisis. Anticentromere antibody alone was identified, and not anti-DNA topoisomerase I antibody, anti-RNA polymerase antibodies, anti-Th/To antibodies, or antiribonucleoprotein antibodies, even with use of immunoprecipitation assay. She was successfully treated with angiotensin-converting enzyme inhibitor. This case, scleroderma renal crisis with detection of anticentromere antibody, is thought to be extremely uncommon.
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