-transparent.png){kind=logo}
Regulation of androgen receptor activity by tyrosine phosphorylation. 2006
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
The androgen receptor (AR) is essential for the growth of prostate cancer cells. Here, we report that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. Mutation of the major tyrosine phosphorylation site in AR significantly inhibits the growth of prostate cancer cells under androgen-depleted conditions. The Src tyrosine kinase appears to be responsible for phosphorylating AR, and there is a positive correlation of AR tyrosine phosphorylation with Src tyrosine kinase activity in human prostate tumors. Our data collectively suggest that growth factors and their downstream tyrosine kinases, which are elevated during hormone-ablation therapy, can induce tyrosine phosphorylation of AR and such modification may be important for prostate tumor growth under androgen-depleted conditions.
Related Publications
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
March 2006,
Neuroscience letters,
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
April 2004,
The Journal of biological chemistry,
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
June 2013,
Seikagaku. The Journal of Japanese Biochemical Society,
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
August 2002,
The Journal of biological chemistry,
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
June 1996,
Science (New York, N.Y.),
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
October 2002,
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology,
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
July 2004,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
September 2000,
Archives of biochemistry and biophysics,
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
June 2020,
Journal of cellular physiology,
Zhiyong Guo, and
Bojie Dai, and
Tianyun Jiang, and
Kexin Xu, and
Yingqiu Xie, and
Oekyung Kim, and
Issa Nesheiwat, and
Xiangtian Kong, and
Jonathan Melamed, and
Venkatesh D Handratta, and
Vincent C O Njar, and
Angela M H Brodie, and
Li-Rong Yu, and
Timothy D Veenstra, and
Hegang Chen, and
Yun Qiu
May 2016,
The Journal of biological chemistry,
