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Synthesis and structure-activity studies of antofine analogues as potential anticancer agents. 2007
Ye Fu, and
Sang Kook Lee, and
Hye-Young Min, and
Taeho Lee, and
Jaekwang Lee, and
Maosheng Cheng, and
Sanghee Kim
College of Pharmacy, Seoul National University, San 56-1, Shilim, Kwanak, Seoul 151-742, Republic of Korea.
Due to the profound cytotoxicities and interesting biochemical aspects, phenanthroindolizidine alkaloids have received an attention as potential therapeutic leads. To define the features of the molecule that are essential for cytotoxicity, we have synthesized and evaluated a series of phenanthroindolizidine alkaloid, antofine, analogues with different substituents on the phenanthrene ring. The systematic structure activity relationship studies elucidate the essential functional group requirement of phenanthrene ring, providing the basis for further development of phenanthroindolizidine alkaloids.
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