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Synthesis and antioxidant evaluation of novel silybin analogues. 2006
Leixiang Yang, and
Jingxu Gong, and
Feng Wang, and
Yongmin Zhang, and
Yanguang Wang, and
Xiaojiang Hao, and
Xiumei Wu, and
Hua Bai, and
Joachim Stöckigt, and
Yu Zhao
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 353 Yan an Road, Hangzhou 310031, PR China.
In this work, we evaluated the antioxidant properties of the eight novel silybin analogues for their capacity to scavenge free radicals including superoxide anion radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in vitro. Compound 7d demonstrated an excellent antioxidant effect in scavenging superoxide anion free radical with an IC50 value of 26.5 microM, while the IC50 of quercetin (the reference compound) was 38.1 microM. Compounds 7b, 7e, 7h showed certain scavenging activities for both types of free radicals.
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