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This study examined the effects of electroconvulsive shock (ECS) on interstitial concentrations of dopamine (DA) and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the purine metabolite uric acid, in the striatum using on-line microdialysis in freely moving rats. Interstitial striatal DA increased to 1310% of baseline when the ECS was administered 18 to 24 hours after implantation of the dialysis probe. DOPAC (+ 19%), HVA (+ 30%), 5-HIAA (+10%), and uric acid (+111%) were increased to a smaller extent. The ECS-induced increase in DA was derived from a Ca++ sensitive pool since perfusion of a modified solution in which Ca++ had been replaced with Mg++ blocked this effect.
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
May 2006,
Brain research bulletin,
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
March 1996,
Synapse (New York, N.Y.),
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
February 1988,
Journal of neurochemistry,
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
November 1992,
Journal of neurochemistry,
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
November 2002,
Environmental health perspectives,
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
July 1992,
European journal of pharmacology,
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
January 1992,
Life sciences,
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
June 1993,
Brain research,
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
January 1999,
Brain research,
G G Nomikos, and
A P Zis, and
G Damsma, and
H C Fibiger
January 1997,
Journal of neural transmission (Vienna, Austria : 1996),
