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Poly(adenosine diphosphoribose) (ADPR) synthase activities of nuclei isolated from normal human and leukemic leukocytes were assayed by incubation with radioactive NAD+. The synthase activity of leukemic leukocyte nuclei was significantly higher than that of normal leukocyte nuclei. The average length of polymers formed by isolated leukemic nuclei under the prescribed experimental condition ranged from 3.1 to 5.3 ADPR residues per chain, while those produced by normal leukocytes nuclei was 1.7 and 2.6 residues per chain. Isolated leukemic and normal leukocyte nuclei were incubated with and without NAD+ and the ability to carry out DNA synthesis was measured. The endogenous DNA synthesis of NAD-treated and untreated nuclei was the same. This finding parallels the result obtained with Novikoff hepatoma cell nuclei and differs from the observation with rat liver or testis nuclei.
L Burzio, and
L Reich, and
S S Koide
June 1959,
The Journal of laboratory and clinical medicine,
L Burzio, and
L Reich, and
S S Koide
July 1976,
Biochemical and biophysical research communications,
L Burzio, and
L Reich, and
S S Koide
December 1962,
Bollettino della Societa italiana di biologia sperimentale,
L Burzio, and
L Reich, and
S S Koide
July 1957,
Bollettino della Societa italiana di biologia sperimentale,
L Burzio, and
L Reich, and
S S Koide
January 1973,
Revue roumaine de medecine interne (1964),
L Burzio, and
L Reich, and
S S Koide
February 1995,
Clinical cancer research : an official journal of the American Association for Cancer Research,
L Burzio, and
L Reich, and
S S Koide
June 1963,
Bollettino della Societa italiana di biologia sperimentale,
L Burzio, and
L Reich, and
S S Koide
January 1963,
Enzymologia biologica et clinica,
L Burzio, and
L Reich, and
S S Koide
November 1970,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
L Burzio, and
L Reich, and
S S Koide
October 1960,
Blood,
