-transparent.png){kind=logo}
The effects of intravenous gammaglobulin (IVGG) on changes in the peripheral blood mononuclear cell subsets during acute Kawasaki disease (KD) were studied by a random selection trial of IVGG plus Aspirin (group G) compared to Aspirin alone (group A). Group G received IVGG with 200 mg/kg per day x 5 dose. The absolute counts of peripheral blood mononuclear cell subsets were assayed by a fluorescence-activated cell sorter using monoclonal antibodies of Leu series. Before therapy, patients in each treatment group had increased counts of CD14 + macrophage/monocytes compared to healthy childhood controls (P less than 0.01). After IVGG treatment group G underwent a greater decrease in their CD14 + macrophage/monocyte counts (P less than 0.01) than group A. The changes of CD3+ T cells. Leu 7+ NK/K cells and CD19+ B cells in the peripheral blood mononuclear cell subsets with treatment in group G, were similar to those in group A. These results suggest the possibility that IVGG therapy is effective in KD by modulating macrophages/monocytes.
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
November 1985,
Lancet (London, England),
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
October 1988,
Lancet (London, England),
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
July 1998,
Pathology international,
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
November 1984,
Lancet (London, England),
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
December 1983,
Lancet (London, England),
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
June 2000,
Pediatrics,
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
May 1978,
British journal of cancer,
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
September 2006,
Singapore medical journal,
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
May 1992,
Archives of disease in childhood,
S Furukawa, and
T Matsubara, and
K Jujoh, and
K Sasai, and
S Nakachi, and
T Sugawara, and
K Yabuta, and
H Kato
January 1998,
Przeglad lekarski,
