Biomaterial Database

Re: loratadine exerts estrogen-like effects and disrupts penile development in the mouse. 2006

Kimberley Anne Treinen

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010413	Penis	The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.	Glans Penis,Penis, Glans
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D017336	Loratadine	A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.	4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester,Alavert,Claritin,Clarium,Sch-29851,Sch 29851,Sch29851
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D039563	Histamine H1 Antagonists, Non-Sedating	A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.	Second Generation Antihistamine,Second Generation H1 Antagonist,Third Generation H1 Antagonist,H1 Antihistamines, Non-Sedating,Second Generation Antihistamines,Second Generation H1 Antagonists,Third Generation H1 Antagonists,Antihistamine, Second Generation,Antihistamines, Second Generation,Generation Antihistamine, Second,H1 Antihistamines, Non Sedating,Histamine H1 Antagonists, Non Sedating,Non-Sedating H1 Antihistamines