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The expression of multiple cellular proto-oncogenes and the in vitro anchorage-independent growth of normal human epidermal keratinocytes and several human squamous cell carcinoma cell lines were studied and correlated. Squamous cell carcinoma cell lines KB, Si Ha, HEp-2, and Fa Du showed high anchorage independency, and MS 751 and A-253 cell lines had minimum independency. However, the normal keratinocytes and the A-431 cell line did not show anchorage-independent growth. Both the normal human epidermal keratinocytes and cancer cell lines expressed multiple proto-oncogenes such as src, erb B-1, abl, fos, raf, H-ras, and myc, and the amount of expression of these oncogenes was notably higher in the cancer cell lines than in the normal keratinocytes. The expression of proto-oncogenes from the monolayer cultures of the cancer cell lines is poorly correlated with the anchorage independency of the cells. These data indicate that the anchorage independency is not directly linked to the expression of specific cellular proto-oncogene(s) of the monolayer cancer cell cultures.
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
January 1986,
Doklady Akademii nauk SSSR,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
October 1985,
Biochemical and biophysical research communications,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
November 1998,
Microscopy research and technique,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
August 1988,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
August 1989,
Experimental cell research,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
October 1989,
International journal of cancer,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
May 1990,
Biochemical and biophysical research communications,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
January 1988,
Reproduction, nutrition, developpement,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
July 2006,
Archives of oral biology,
K Kim, and
E Akoto-Amanfu, and
H M Cherrick, and
N H Park
July 1997,
Hepatology (Baltimore, Md.),
