-transparent.png){kind=logo}
Mongolian gerbils of both sexes received a single daily dose of 40 mg/kg of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) over 4 consecutive days. On the fifth day the animals were treated with 15 mg/kg i.p. of L-deprenyl or amantadine or the combination of both drugs. At different time intervals (1, 2, 5 hours) the animals were sacrificed. In the caudate nuclei dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured by an HPLC technique. MPTP affected the dopaminergic (HVA -25%) as well as the serotoninergic system (5-HT -54%, 5-HIAA -31%). L-deprenyl and amantadine accumulated DA and 5-HT in the MPTP affected caudates. Synergistic effects of the drug combination could be proven.
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
January 2008,
Psychopharmacology,
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
January 1978,
Journal of neural transmission,
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
August 1970,
Drug and therapeutics bulletin,
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
August 1972,
Australian and New Zealand journal of medicine,
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
December 1991,
Journal of neuroscience research,
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
October 1970,
Lancet (London, England),
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
January 1994,
Progress in neuro-psychopharmacology & biological psychiatry,
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
January 2001,
Eksperimental'naia i klinicheskaia farmakologiia,
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
October 1971,
Minerva medica,
W D Rausch, and
E Schallauer, and
W W Chan, and
P Riederer, and
M Weiser
November 1969,
Wisconsin medical journal,
