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Tenascin (TN) is a hexameric extracellular matrix glycoprotein that is highly expressed in solid tumors but has a restricted distribution in normal adult tissues. Each TN subunit is composed of segments with high homology to the sequences of epidermal growth factor, fibronectin and fibrinogen. Furthermore, it has been suggested that TN could modulate epithelial-mesenchymal and neuronal-glial interactions. Here, using a cDNA probe to human TN, we have carried out Southern blot analysis of the genomic DNAs from a panel of human-hamster somatic cell hybrids carrying different complements of human chromosomes. The results demonstrate that the human TN gene is located on chromosome 9. Furthermore, in situ hybridization studies demonstrate that human TN is located at 9q32-q34.
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
July 1990,
Genomics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
January 1991,
Cytogenetics and cell genetics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
November 1994,
Genomics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
January 1980,
Cytogenetics and cell genetics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
June 1989,
Human genetics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
November 1987,
Somatic cell and molecular genetics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
April 1988,
Genomics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
January 2000,
Cytogenetics and cell genetics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
December 1991,
Genomics,
M Rocchi, and
N Archidiacono, and
G Romeo, and
M Saginati, and
L Zardi
January 1997,
Cytogenetics and cell genetics,
