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A simple and precise high performance liquid chromatographic method for the determination of mexiletine in human serum or plasma is described. Following addition of N-propionylprocainamide as internal standard the specimens are extracted, under basic conditions, into methylene chloride. After removal of the aqueous layer the drug is back-extracted into dilute acid, which is then injected directly for analysis. The extraction efficiency is 79% for both mexiletine and internal standard, and the assay is linear to 4 mg/L (twice upper therapeutic concentration). Inter-run coefficients of variation are 3.0% or less. The relative retention time of mexiletine to internal standard averages 1.3. An adaptation of this method is described for an alternate application to the analysis of tocainide, procainamide and N-acetylprocainamide.
E vasBinder, and
T Annesley
February 1986,
Research communications in chemical pathology and pharmacology,
E vasBinder, and
T Annesley
June 1983,
Therapeutic drug monitoring,
E vasBinder, and
T Annesley
May 1984,
Clinical chemistry,
E vasBinder, and
T Annesley
June 1988,
Yao xue xue bao = Acta pharmaceutica Sinica,
E vasBinder, and
T Annesley
October 1982,
Clinical chemistry,
E vasBinder, and
T Annesley
January 1977,
Clinical chemistry,
E vasBinder, and
T Annesley
April 1979,
Journal of pharmaceutical sciences,
E vasBinder, and
T Annesley
December 1976,
Journal of chromatography,
E vasBinder, and
T Annesley
January 1981,
Therapeutic drug monitoring,
E vasBinder, and
T Annesley
June 1978,
Journal of pharmaceutical sciences,
