-transparent.png){kind=logo}
Protection against aerosol challenge with > 300 MLD of Yersinia pestis was observed 7 days after a single immunisation of mice with the F1+V vaccine. At day 60, mice were protected against injected challenge (10(7)MLD) in a vaccine dose-related manner. Recall responses to rV in splenocytes ex vivo at day 98 correlated significantly (p<0.001) with the immunising dose-level of V antigen; no memory response or anti-V serum IgG was detected in killed whole cell vaccine (KWCV) recipients. This may explain the susceptibility of KWCV recipients to aerosol challenge and the enhanced protection conferred by the F1+V sub-unit vaccine, particularly since the anti-F1 responses induced by either vaccine were similarly IgG1-polarised.
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
April 2009,
Vaccine,
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
July 1998,
Vaccine,
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
January 2005,
Biotechnology progress,
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
June 2011,
Vaccine,
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
January 1951,
Rocky Mountain medical journal,
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
June 2005,
Infection and immunity,
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
July 2009,
MMWR. Morbidity and mortality weekly report,
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
July 2001,
Vaccine,
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
January 2007,
Journal of immunology (Baltimore, Md. : 1950),
E D Williamson, and
A J Stagg, and
S M Eley, and
R Taylor, and
M Green, and
S M Jones, and
R W Titball
November 1996,
Infection and immunity,
