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Newly developed substance P (SP) analogs with altered N-terminal sequences which equalize the lipophilicity of the N-terminal and C-terminal elements and of their fusion product were examined using i.t. injection in mice. I.t. injection of either the full length analog or the C-terminal hexapeptide (CP) produced biting and scratching behavior similar to that elicited by SP. SPF was approximately 5-fold and CP 14-fold less potent than native SP. The N-terminal peptide (NP) was inactive by itself but inhibited CP-elicited behavior. Naloxone antagonized this action of NP and shifted the SPF dose-response curve 4-fold to the left. However, naloxone had no effect on the action of CP or on the action of any of the native neurokinins. The results are consistent with the hypothesis that N- and C-terminal analogs of SP can have opioid and SP-like actions, respectively, in the CNS of rodents. Furthermore, analogs of SP which include at least the terminal tetrapeptide retain neurokinin activity.
S Z Lei, and
A W Lipkowski, and
G L Wilcox
May 1981,
Experientia,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
April 1984,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
January 1979,
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
August 1987,
Chemical & pharmaceutical bulletin,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
August 1979,
Archives internationales de pharmacodynamie et de therapie,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
August 2003,
Neuroreport,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
November 2016,
Fertility and sterility,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
October 1991,
The Journal of pharmacology and experimental therapeutics,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
May 1990,
Nihon rinsho. Japanese journal of clinical medicine,
S Z Lei, and
A W Lipkowski, and
G L Wilcox
July 1987,
Neuropeptides,
