MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy. 2007

José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
Department of Physiology, Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan 14080, Mexico City, Mexico.

The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 ethnically matched healthy controls using the polymerase chain reaction-sequence specific oligonucleotides (PCR-SSO) technique. IDC patients showed increased frequencies of HLA-DR4 (pC=0.02, OR=1.87), HLA-DQB1*0301 (pC=0.02, OR=1.92) and HLA-DQB1*0302 (pC=0.02, OR=1.87) when compared to healthy controls. On the other hand, IDC patients also showed decreased frequencies of HLA-DR11 allele (pC=0.03, OR=0.26) and HLA-DQB1*0201 (pC=0.04, OR=0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population.

UI MeSH Term Description Entries
D008800 Mexico A country in NORTH AMERICA, bordering the Caribbean Sea and the Gulf of Mexico, between BELIZE and the UNITED STATES, and bordering the North Pacific Ocean, between Guatemala and the UNITED STATES.
D002311 Cardiomyopathy, Dilated A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein. Cardiomyopathy, Congestive,Congestive Cardiomyopathy,Dilated Cardiomyopathy,Cardiomyopathy, Dilated, 1a,Cardiomyopathy, Dilated, Autosomal Recessive,Cardiomyopathy, Dilated, CMD1A,Cardiomyopathy, Dilated, LMNA,Cardiomyopathy, Dilated, With Conduction Defect 1,Cardiomyopathy, Dilated, with Conduction Deffect1,Cardiomyopathy, Familial Idiopathic,Cardiomyopathy, Idiopathic Dilated,Cardiomyopathies, Congestive,Cardiomyopathies, Dilated,Cardiomyopathies, Familial Idiopathic,Cardiomyopathies, Idiopathic Dilated,Congestive Cardiomyopathies,Dilated Cardiomyopathies,Dilated Cardiomyopathies, Idiopathic,Dilated Cardiomyopathy, Idiopathic,Familial Idiopathic Cardiomyopathies,Familial Idiopathic Cardiomyopathy,Idiopathic Cardiomyopathies, Familial,Idiopathic Cardiomyopathy, Familial,Idiopathic Dilated Cardiomyopathies,Idiopathic Dilated Cardiomyopathy
D005802 Genes, MHC Class II Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and include H-2M, I-A, and I-E loci in mice. Class II Genes,Genes, Class II,Genes, HLA Class II,MHC Class II Genes,Class II Gene,Gene, Class II
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016133 Polymerase Chain Reaction In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships. Anchored PCR,Inverse PCR,Nested PCR,PCR,Anchored Polymerase Chain Reaction,Inverse Polymerase Chain Reaction,Nested Polymerase Chain Reaction,PCR, Anchored,PCR, Inverse,PCR, Nested,Polymerase Chain Reactions,Reaction, Polymerase Chain,Reactions, Polymerase Chain
D020022 Genetic Predisposition to Disease A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. Genetic Predisposition,Genetic Susceptibility,Predisposition, Genetic,Susceptibility, Genetic,Genetic Predispositions,Genetic Susceptibilities,Predispositions, Genetic,Susceptibilities, Genetic

Related Publications

José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
January 2004, Human immunology,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
October 1995, Journal of molecular and cellular cardiology,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
January 1998, Scandinavian journal of rheumatology,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
June 2010, Tissue antigens,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
May 2004, Immunology letters,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
November 2003, International journal of cardiology,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
June 1997, Journal of cardiac failure,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
July 2008, Zhonghua xin xue guan bing za zhi,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
January 2018, Scientific reports,
José Manuel Rodríguez-Pérez, and José Manuel Fragoso, and Edith Alvarez-León, and Nancy Martínez-Rodríguez, and Guillermo J Gallardo, and Selene Inés-Real, and Julio Granados, and Pedro A Reyes, and Gilberto Vargas-Alarcón
October 2011, Journal of immunology (Baltimore, Md. : 1950),
Copied contents to your clipboard!