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Synthesis of purin-2-yl carboxylate from O6-methylguanosine. 2005

Tokumi Maruyama, and Nobuyasu Moriwaka, and Yosuke Demizu, and Masami Ohtsuka
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Shido 1314-1, Sanuki City, Kagawa 769-2193, Japan. maruyama@ph.bunri-u.ac.jp

O6-methylguanosine derivative was treated with sodium nitrite or isoamylnitrite in the presence of the carboxylic acid to give the purin-2-yl carboxylate (2), an unusual product bearing a carboxylic group at 2-position of purine moiety.

UI MeSH Term Description Entries
D011684 Purine Nucleosides Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES. Purine Nucleoside,Nucleoside, Purine,Nucleosides, Purine
D006151 Guanosine A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)

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