BIOMAT Database Logo BIOMAT Database Logo

Telomerase inhibition by 3'-azido-2', 3'-dideoxynucleoside 5'-triphosphates and telomere shortening in human cultured cells by the corresponding nucleosides. 2006

Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Department of Biosciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409-0193, Japan.

Telomerase is believed to be a good target for the development of antitumor agents. In this study, 3'-azido-2',3'-dideoxy-2-aminoadenosine (AZddAA), 3'-azido-2',3'-dideoxyadenosine (AZddA), 9-(3-azido-2,3-dideoxy-beta-D-ribofuranosyl)-2-aminopurine (AZddAP), 3'-azido-2-chloro-2',3'-dideoxyadenosine (AZddClA) and their triphosphate derivatives were synthesized. Telomerase assay studies showed that the 2-amino group plays an important role in the inhibitory activity of these compounds. In addition, AZddAA was found to cause telomere shortening in of HL60 cells in culture.

UI MeSH Term Description Entries
D003854 Deoxyribonucleotides A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group. Deoxyribonucleotide
D004791 Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D001386 Azides Organic or inorganic compounds that contain the -N3 group. Azide
D015224 Dideoxynucleosides Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription. 2',3'-Dideoxynucleosides,Dideoxyribonucleosides,ddNus,2',3' Dideoxynucleosides
D016615 Telomere A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs. Telomeres
D018922 HL-60 Cells A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8) HL60 Cells,Cell, HL60,Cells, HL60,HL 60 Cells,HL-60 Cell,HL60 Cell
D019098 Telomerase An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES. Telomerase Catalytic Subunit,Telomerase Reverse Transcriptase,Telomerase Reverse Transcriptase Catalytic Subunit,Catalytic Subunit, Telomerase,Reverse Transcriptase, Telomerase,Subunit, Telomerase Catalytic,Transcriptase, Telomerase Reverse

Related Publications

Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Inhibition of HIV reverse transcriptase by 2',3'-dideoxynucleoside triphosphates.
December 1987, Biochemical pharmacology,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Irreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment.
May 1998, Biochemical and biophysical research communications,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Inhibition of human telomerase by L-enantiomers of natural 2'-deoxyribonucleoside 5'-triphosphates.
January 2001, Nucleosides, nucleotides & nucleic acids,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates.
April 1981, Biochemistry,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
August 1998, Biochemical and biophysical research communications,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors.
October 2010, Oncology reports,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Inhibitory effects of various 2',3'-dideoxynucleoside 5'-triphosphates on the utilization of 2'-deoxynucleoside 5'-triphosphates by terminal deoxynucleotidyltransferase from calf thymus.
May 1990, Biochimica et biophysica acta,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxynucleoside triphosphates: template dependence, and combination with phosphonoformate.
May 1989, Virus genes,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Human telomerase inhibition by 7-deaza-2'-deoxypurine nucleoside triphosphates.
December 1996, Biochemistry,
Toyofumi Yamaguchi, and Xiaohong Liu, and Tsukasa Ogawara, and Motoko Inomata, and Mineo Saneyoshi
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells.
September 1999, Genes & development,
Copied contents to your clipboard!