Morphine and yohimbine regulate midkine gene expression in the rat hippocampus. 2007

Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
Department of Molecular and Experimental Medicine and Cell Biology, The Scripps Research Institute, La Jolla, CA, USA.

Pleiotrophin and midkine are two recently discovered growth factors that promote survival and differentiation of catecholaminergic neurons. Chronic opioid stimulation has been reported to induce marked alterations of the locus coeruleus-hippocampus noradrenergic pathway, an effect that is prevented when opioids are coadministered with the alpha2-adrenoceptor antagonist yohimbine. The present work tries to examine a possible link between yohimbine reversal of morphine effects and pleiotrophin/midkine activation in the rat hippocampus by studying the levels of expression of pleiotrophin and midkine in response to acute and chronic administration of morphine, yohimbine and combinations of both drugs. Pleiotrophin gene expression was not altered by any treatment; however midkine mRNA levels were increased after chronic treatment with morphine. Chronic administration of yohimbine alone also increased midkine expression levels, whereas yohimbine and morphine administered together exhibited summatory effects on the upregulation of midkine expression levels. The data suggest that midkine could play a role in the prevention of opioid-induced neuroadaptations in hippocampus by yohimbine.

UI MeSH Term Description Entries
D008297 Male Males
D009020 Morphine The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Morphine Sulfate,Duramorph,MS Contin,Morphia,Morphine Chloride,Morphine Sulfate (2:1), Anhydrous,Morphine Sulfate (2:1), Pentahydrate,Oramorph SR,SDZ 202-250,SDZ202-250,Chloride, Morphine,Contin, MS,SDZ 202 250,SDZ 202250,SDZ202 250,SDZ202250,Sulfate, Morphine
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000078792 Midkine A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury. Amphiregulin-Associated Protein,Cytokine MK,Amphiregulin Associated Protein
D000701 Analgesics, Opioid Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. Opioid,Opioid Analgesic,Opioid Analgesics,Opioids,Full Opioid Agonists,Opioid Full Agonists,Opioid Mixed Agonist-Antagonists,Opioid Partial Agonists,Partial Opioid Agonists,Agonist-Antagonists, Opioid Mixed,Agonists, Full Opioid,Agonists, Opioid Full,Agonists, Opioid Partial,Agonists, Partial Opioid,Analgesic, Opioid,Full Agonists, Opioid,Mixed Agonist-Antagonists, Opioid,Opioid Agonists, Full,Opioid Agonists, Partial,Opioid Mixed Agonist Antagonists,Partial Agonists, Opioid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D015016 Yohimbine A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION. Rauwolscine,Aphrodine Hydrochloride,Aphrodyne,Corynanthine,Corynanthine Tartrate,Pluriviron,Rauhimbine,Yocon,Yohimbin Spiegel,Yohimbine Houdé,Yohimbine Hydrochloride,Yohimex,Hydrochloride, Aphrodine,Hydrochloride, Yohimbine,Tartrate, Corynanthine
D016207 Cytokines Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. Cytokine

Related Publications

Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
February 2007, Neuropharmacology,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
October 2002, Neuropharmacology,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
December 2008, Brain research,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
January 2017, PloS one,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
April 2001, Life sciences,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
January 2006, Neuroreport,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
January 1992, European journal of pharmacology,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
February 1995, Neuroscience letters,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
May 2003, Neurobiology of learning and memory,
Laura Ezquerra, and Carmen Pérez-García, and Elisa Garrido, and Carmen Díez-Fernández, and Thomas F Deuel, and Luis F Alguacil, and Gonzalo Herradón
January 2001, Neuroscience,
Copied contents to your clipboard!