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The unusual combination of a normal pattern reversal VEP and a delayed flash VEP has been reported in patients with dementia of Alzheimer's type (DAT). Hyoscine hydrobromide has been reported to produce a similar VEP abnormality in young, healthy subjects. In the present study, we assessed the relative sensitivity of DAT patients and healthy young, middle-aged and elderly subjects to temporary cholinergic blockade. We report VEP latency values following 3 doses of scopolamine and after a peripheral anticholinergic agent. Flash P2 latency was not significantly slower in DAT patients than in the healthy elderly. Scopolamine increased P2 latency in the young controls but did not affect any other group. The pattern reversal P100 was normal in DAT, and a significant increase in latency occurred following scopolamine administration in both the control and patient groups.
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
January 1990,
Psychopharmacology,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
January 2000,
Vojnosanitetski pregled,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
March 1995,
Optometry and vision science : official publication of the American Academy of Optometry,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
July 2013,
International journal of psychophysiology : official journal of the International Organization of Psychophysiology,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
January 1983,
Electromyography and clinical neurophysiology,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
May 2015,
Muscle & nerve,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
December 1987,
Documenta ophthalmologica. Advances in ophthalmology,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
January 1982,
Advances in neurology,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
July 2005,
The International journal of neuroscience,
P G Ray, and
K J Meador, and
D W Loring, and
A M Murro, and
J J Buccafusco, and
X H Yang, and
E Y Zamrini, and
W O Thompson, and
E E Thompson
December 1990,
Electromyography and clinical neurophysiology,
