-transparent.png){kind=logo}
The aim of this study was to determine the side effects of standard antituberculosis therapy with isoniazid, rifampicin, pyrazinamide and streptomycine in patients treated for tuberculosis. One hundred eighty nine patients with proven tuberculosis, who initially received standard antituberculosis therapy, were retrospectively studied. Begaud and coll's method of side effects drugs imputability elaborated in 1999 was used in our study. Side effects related to therapy were present in 31.7% of the studied population. Gastrointestinal side effect was the most common (13.2%), isoniazid, rifampicin and pyrazinamide were often incriminated. The significant risk factors of hepatotoxicity were female gender (OR : 10.59) and concomitant hepatotoxic drugs (OR 6). Chocleovestibular toxicity was associated significantly with female gender (OR : 8.03) and diabetes mellitus (OR : 6.13). Patients aged above 50, proved to be at risk for pyrazinomide intolerance and females for streptomycine. The study did not reveal any susceptibility to isoniazid and rifadine intolerance.
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
April 2004,
American journal of respiratory and critical care medicine,
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
June 1986,
Zhonghua jie he he hu xi xi ji bing za zhi = Chinese journal of tuberculosis and respiratory diseases,
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
December 1979,
Chest,
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
February 1996,
Lancet (London, England),
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
October 1990,
Journal of the Indian Medical Association,
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
January 1997,
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia,
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
December 2001,
Thorax,
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
February 2004,
American journal of respiratory and critical care medicine,
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
May 2004,
American journal of respiratory and critical care medicine,
Leila El Gharbi, and
Mohamed Ali Baccar, and
Saloua Azzabi, and
Hichem Aouina, and
Houda Kallel, and
Riadh Daghfous, and
Hend Bouacha
January 2015,
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia,
