Biomaterial Database

Silent corticotroph cell pituitary adenoma in a struma ovarii. 2007

Michael S Waugh, and Alejandro Peralta Soler, and Stanley J Robboy

Department of Pathology, Duke University Health System, Durham, North Carolina, USA. michael.waugh@duke.edu

This is the first report of a silent corticotroph cell pituitary adenoma arising in a struma ovarii. The patient, a 79-year-old woman, was found to have an asymptomatic left-sided adnexal mass confirmed by vaginal sonography to be a complex cystic and solid tumor. Pathological analysis demonstrated an 8-cm partially cystic struma ovarii in which there was a focus of predominantly basophilic adenohypophyseal cells arranged in a diffuse pattern, adjacent to mature neural tissue containing numerous Herring bodies. The epithelial lining cells of the colloid-filled small and cystic follicles were immunoreactive for thyroglobulin. The pituitary cells were predominantly immunoreactive for adrenocorticotropic hormone, in addition to synaptophysin.

UI	MeSH Term	Description	Entries
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D013330	Struma Ovarii	A rare teratoid tumor of the ovary composed almost entirely of thyroid tissue, with large follicles containing abundant colloid. Occasionally there are symptoms of hyperthyroidism. 5-10% of struma ovarii become malignant, the only absolute criterion for which is the presence of metastasis. (Dorland, 27th ed; Segen, Dictionary of Modern Medicine, 1992)
D049913	ACTH-Secreting Pituitary Adenoma	A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.	Corticotroph Adenoma,Pituitary Adenoma, ACTH-Secreting,Pituitary Corticotropin-Secreting Adenoma,ACTH-Producing Pituitary Adenoma,ACTH Producing Pituitary Adenoma,ACTH Secreting Pituitary Adenoma,ACTH-Producing Pituitary Adenomas,ACTH-Secreting Pituitary Adenomas,Adenoma, Corticotroph,Adenomas, Corticotroph,Corticotroph Adenomas,Corticotropin-Secreting Adenoma, Pituitary,Corticotropin-Secreting Adenomas, Pituitary,Pituitary Adenoma, ACTH Secreting,Pituitary Adenoma, ACTH-Producing,Pituitary Adenomas, ACTH-Producing,Pituitary Adenomas, ACTH-Secreting,Pituitary Corticotropin Secreting Adenoma,Pituitary Corticotropin-Secreting Adenomas
D052680	Corticotrophs	Anterior pituitary cells that produce ADRENOCORTICOTROPHIC HORMONE.	Pituitary Adrenocorticotropin-Secreting Cells,Pituitary ACTH-Producing Cells,Pituitary ACTH-Secreting Cells,ACTH-Producing Cell, Pituitary,ACTH-Producing Cells, Pituitary,ACTH-Secreting Cell, Pituitary,ACTH-Secreting Cells, Pituitary,Adrenocorticotropin-Secreting Cell, Pituitary,Adrenocorticotropin-Secreting Cells, Pituitary,Cells, Pituitary Adrenocorticotropin-Secreting,Corticotroph,Pituitary ACTH Producing Cells,Pituitary ACTH Secreting Cells,Pituitary ACTH-Producing Cell,Pituitary ACTH-Secreting Cell,Pituitary Adrenocorticotropin Secreting Cells,Pituitary Adrenocorticotropin-Secreting Cell