-transparent.png){kind=logo}
The interferon-inducing activity of new derivatives of gossypol, a low molecular weight natural polyphenol, and its model compounds was studied in regard to their chemical structure. The active groups required for development of optimal interferon inductors on the basis of the natural polyphenols were defined. As a result of the studies the new interferon inductor AC-1 which is a condensation product of gossypol, a natural polyphenol, and a cellulose derivative was isolated. The interferon-inducing activity of AC-1 was investigated with respect to its dose and the administration route. High interferon-inducing activity of the interferon inductor after its administration by any route in doses of 10 to 100 mg/kg was demonstrated. The serum interferon titers reached 2560 units/ml.
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
September 1946,
American review of tuberculosis,
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
April 1952,
Produits pharmaceutiques,
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
May 1952,
Produits pharmaceutiques,
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
March 1951,
Bollettino della Societa italiana di biologia sperimentale,
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
January 1979,
Journal of immunology (Baltimore, Md. : 1950),
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
January 1985,
Meditsinskaia parazitologiia i parazitarnye bolezni,
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
September 1987,
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology,
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
January 1978,
Doklady Akademii nauk SSSR,
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
January 1978,
General pharmacology,
A M Saĭitkulov, and
F I Ershov, and
Kh A Aslanov, and
E B Tazupakhova, and
S A Maulianov, and
G Sh Achilova, and
S Kh Amanova
July 1965,
Biochemical pharmacology,
