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9-beta-d-Arabinofuranosylhypoxanthine 5'-monophosphate (ara-HxMP) significantly controlled the development of encephalitis produced by deoxyribonucleic acid viruses in mice. In most experiments the activities of ara-HxMP and 9-beta-d-arabinofuranosyladenine (ara-A) were determined simultaneously. In the intracerebral (target organ) and intravenous therapy experiments, ara-HxMP had a pronounced advantage over ara-A since the water solubility of ara-HxMP enabled it to be used in much higher concentrations. In experiments where the two drugs were administered intraperitoneally or orally they exhibited similar activity. In several intraperitoneal therapy experiments ara-HxMP was tested alone, using various treatment schedules and dosages. In these experiments, efficacy was observed in groups that had treatments initiated as late as 72 h after virus inoculation.
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
December 1976,
Antimicrobial agents and chemotherapy,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
October 1975,
Antimicrobial agents and chemotherapy,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
October 1975,
Antimicrobial agents and chemotherapy,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
June 1976,
The Journal of infectious diseases,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
January 1981,
Antimicrobial agents and chemotherapy,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
May 1976,
Cancer research,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
June 1982,
Biochemical pharmacology,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
July 1978,
Cancer research,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
January 1981,
Chemotherapy,
L B Allen, and
J M Thompson, and
J H Huffman, and
G R Revankar, and
R L Tolman, and
L N Simon, and
R K Robins, and
R W Sidwell
November 1980,
Cancer research,
