Biomaterial Database

Neurological manifestations of cervical spondylosis: an overview of signs, symptoms, and pathophysiology. 2007

James S Harrop, and Amgad Hanna, and Marco T Silva, and Ashwini Sharan

Department of Neurosurgery, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA. James.Harrop@jefferson.edu

The neurological manifestations of cervical spondylosis include symptomatic compression of the spinal cord (myelopathy), nerve roots (radiculopathy), or a combination of the two (myeloradiculopathy). The term myeloradiculopathy herein defines these often indistinct and inseparable entities. The pathophysiology of myeloradiculopathy is multifactorial in nature, and the natural history of untreated myeloradiculopathy is not clearly defined. We review the signs, symptoms, and clinical findings of cervical myelopathy, radiculopathy, and myeloradiculopathy. Standard grading techniques are also reviewed.

UI	MeSH Term	Description	Entries
D011843	Radiculopathy	Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.	Nerve Root Avulsion,Nerve Root Compression,Nerve Root Disorder,Radiculitis,Nerve Root Inflammation,Radiculopathy, Cervical,Avulsion, Nerve Root,Avulsions, Nerve Root,Cervical Radiculopathies,Cervical Radiculopathy,Compression, Nerve Root,Compressions, Nerve Root,Inflammation, Nerve Root,Nerve Root Avulsions,Nerve Root Compressions,Nerve Root Disorders,Nerve Root Inflammations,Radiculitides,Radiculopathies,Radiculopathies, Cervical
D002574	Cervical Vertebrae	The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.	Cervical Spine,Cervical Spines,Spine, Cervical,Vertebrae, Cervical
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013117	Spinal Cord Compression	Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.	Conus Medullaris Syndrome,Myelopathy, Compressive,Extramedullary Spinal Cord Compression,Spinal Cord Compression, Extramedullary,Compression, Spinal Cord,Compressions, Spinal Cord,Compressive Myelopathy,Conus Medullaris Syndromes,Spinal Cord Compressions,Syndrome, Conus Medullaris,Syndromes, Conus Medullaris
D013118	Spinal Cord Diseases	Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.	Myelopathy,Spinal Cord Disorders,Myelopathies,Spinal Cord Disease,Spinal Cord Disorder
D013128	Spinal Osteophytosis	Outgrowth of immature bony processes or bone spurs (OSTEOPHYTE) from the VERTEBRAE, reflecting the presence of degenerative disease and calcification. It commonly occurs in cervical and lumbar SPONDYLOSIS.	Osteophytosis, Spinal,Osteophytoses, Spinal,Spinal Osteophytoses