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Fibroblast secreted proteins participate in the formation of extracellular matrix. Extracellular matrix affects growth factor action, mediates cell adhesion and supports cell growth. Structural and quantitative characteristics of secreted proteins are modified in a similar manner, during both in vivo and in vitro cellular ageing. Such ageing related modifications may either be directly controlled by primary ageing causes, or evolve from a reformation of the extracellular matrix induced by a few ageing defects in key proteins such as fibronectin. They may result in the further inhibition of cell adhesion, cell stimulation by growth factors and, eventually, of cell proliferative ability.
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
January 2009,
PloS one,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
September 1984,
Experimental cell research,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
December 1991,
Annals of the New York Academy of Sciences,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
October 1987,
Leukemia,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
December 1972,
Proceedings of the National Academy of Sciences of the United States of America,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
March 2021,
Scientific reports,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
January 1987,
Cancer investigation,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
March 2018,
Scientific reports,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
April 1984,
The British journal of dermatology,
C S Eleftheriou, and
N B Trakas, and
S J Tzartos
February 1989,
Electrophoresis,
