BIOMAT Database Logo BIOMAT Database Logo

Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients. 2007

Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Department of Clinical Pharmacy, St. Antonius Hospital, P.O. Box 2500, 3430 EM Nieuwegein, The Netherlands. r.peeters@antoniusmesosgroep.nl

A sensitive gas chromatography-mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2 microg/L using a volume of 0.5 mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1%, respectively. The assay covers the linear concentration range of 2-50 microg/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure.

UI MeSH Term Description Entries
D008297 Male Males
D008401 Gas Chromatography-Mass Spectrometry A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds. Chromatography, Gas-Liquid-Mass Spectrometry,Chromatography, Gas-Mass Spectrometry,GCMS,Spectrometry, Mass-Gas Chromatography,Spectrum Analysis, Mass-Gas Chromatography,Gas-Liquid Chromatography-Mass Spectrometry,Mass Spectrometry-Gas Chromatography,Chromatography, Gas Liquid Mass Spectrometry,Chromatography, Gas Mass Spectrometry,Chromatography, Mass Spectrometry-Gas,Chromatography-Mass Spectrometry, Gas,Chromatography-Mass Spectrometry, Gas-Liquid,Gas Chromatography Mass Spectrometry,Gas Liquid Chromatography Mass Spectrometry,Mass Spectrometry Gas Chromatography,Spectrometries, Mass-Gas Chromatography,Spectrometry, Gas Chromatography-Mass,Spectrometry, Gas-Liquid Chromatography-Mass,Spectrometry, Mass Gas Chromatography,Spectrometry-Gas Chromatography, Mass,Spectrum Analysis, Mass Gas Chromatography
D001930 Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. Brain Lacerations,Acute Brain Injuries,Brain Injuries, Acute,Brain Injuries, Focal,Focal Brain Injuries,Injuries, Acute Brain,Injuries, Brain,Acute Brain Injury,Brain Injury,Brain Injury, Acute,Brain Injury, Focal,Brain Laceration,Focal Brain Injury,Injuries, Focal Brain,Injury, Acute Brain,Injury, Brain,Injury, Focal Brain,Laceration, Brain,Lacerations, Brain
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D015742 Propofol An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS. Disoprofol,2,6-Bis(1-methylethyl)phenol,2,6-Diisopropylphenol,Aquafol,Diprivan,Disoprivan,Fresofol,ICI-35,868,ICI-35868,Ivofol,Propofol Abbott,Propofol Fresenius,Propofol MCT,Propofol Rovi,Propofol-Lipuro,Recofol,2,6 Diisopropylphenol,ICI 35,868,ICI 35868,ICI35,868,ICI35868
D018686 Anesthetics, Intravenous Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174) Intravenous Anesthetic,Intravenous Anesthetics,Anesthetic, Intravenous

Related Publications

Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Gas chromatography--mass spectrometric characteristics and assay of tele-methylhistamine.
July 1979, Analytical biochemistry,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Gas chromatographic-mass spectrometric determination of myo-inositol in human cerebrospinal fluid.
August 1985, Journal of neurochemistry,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Comparison between gas chromatography-atomic emission detection and gas chromatography-mass spectrometry for the assay of propofol.
November 1996, Journal of chromatography. B, Biomedical applications,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Gas chromatography-mass spectrometry assay for determination of ketamine in brain.
January 1999, Journal of pharmacological and toxicological methods,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
High-performance liquid chromatographic-mass spectrometric assay of busulfan in serum and cerebrospinal fluid.
October 1992, Journal of chromatography,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Determination of phenylacetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry.
October 1986, Acta medica Okayama,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Simultaneous assay of prostaglandins and thromboxane in the cerebrospinal fluid by gas chromatography-mass spectrometry-selected ion monitoring.
August 1999, Journal of chromatography. B, Biomedical sciences and applications,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Liquid chromatography-mass spectrometry assay for quantification of Gluten Exorphin B5 in cerebrospinal fluid.
June 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Gas chromatographic separation and mass spectrometric identification of polyols in human cerebrospinal fluid and plasma.
August 1977, Acta neurologica Scandinavica,
Mariska Y M Peeters, and Hiltjo Kuiper, and Ben Greijdanus, and Joukje van der Naalt, and Catherijne A J Knibbe, and Donald R A Uges
Extractive acylation and mass spectrometric assay of 3-methoxytyramine, normetanephrine, and metanephrine in cerebrospinal fluid.
September 1985, Analytical biochemistry,
Copied contents to your clipboard!